Collins was a member of Interpen (Intercontinental Penetration Force) that was established in 1961 by Gerry P. Hemming. Other members included Loran Hall, Roy Hargraves, William Seymour, Lawrence Howard, Steve Wilson, Howard K. Davis, James Arthur Lewis, Dennis Harber, Dick Whatley, Bill Dempsey, Ramigo Arce, Ronald Augustinovich, Joe Garman, Edmund Kolby, Ralph Schlafter, Manuel Aguilar and Oscar Del Pinto.
This group of experienced soldiers were involved in training members of the anti-Castro groups funded by the Central Intelligence Agency in Florida in the early 1960s. When the government began to crack down on raids from Florida in 1962, Interpen set up a new training camp in New Orleans. The group carried out a series of raids on Cuba in an attempt to undermine the government of Fidel Castro. This involved a plan to create a war by simulating an attack on Guantanamo Naval Base.
On 25th September, 1963, Silvia Odio had a visit from three men who claimed they were from New Orleans. Two of the men, Leopoldo and Angelo, said they were members of the Junta Revolucionaria. The third man, Leon, was introduced as an American sympathizer who was willing to take part in the assassination of Fidel Castro. After she told them that she was unwilling to get involved in any criminal activity, the three men left.
The following day Leopoldo phoned Odio and told her that Leon was a former Marine and that he was an expert marksman. He added that Leon had said “we Cubans, we did not have the guts because we should have assassinated Kennedy after the Bay of Pigs”. It is believed that Bernardo De Torres was Leopoldo and Edwin Collins was Angelo.
Some researchers believe that a combination of Interpen members and anti-Castro Cubans were involved in the assassination of John F. Kennedy. This included Collins, James Arthur Lewis, Roy Hargraves, Steve Wilson, Gerry P. Hemming, David Morales, Herminio Diaz Garcia, Tony Cuesta, Eugenio Martinez, Virgilio Gonzalez, Felipe Vidal Santiago and William (Rip) Robertson.
Edwin Anderson Collins died in a boating accident in 1964. It is believed he was murdered by a fellow member of Interpen. However, Gerry P. Hemming claims that he was murdered by "fellow-travelers" linked to Fidel Castro.