Edmund Duffy was born in 1899. He joined the Baltimore Sun as a cartoonist in 1924. The following year he went to Tennessee with H. L. Mencken to report on the Scopes Trial. The two men worked together for the next twenty-five years. Mencken valued Duffy's work very highly and once remarked: "Give me a good cartoonist and I can throw out half the editorial staff."
Duffy won the Pulitzer Prize for cartooning three times: An Old Struggle Still Goes On (1931), California Points With Pride (1934) and The Outstretched Hand (1940).
Edmund Duffy died in 1962.